期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 10, 期 4, 页码 275-282出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2014.12.007
关键词
Mucus barrier; Mucus penetrating nanoparticles; Mucus properties; Experimental strategies
Mucus can effectively protect the exposed mucosal surfaces due to its adhesive and viscoelastic properties. Most foreign particulates are efficiently trapped in mucus layers via steric obstruction and adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on their location sites. This article focuses on describing the tenacious mucus barrier properties, the strategies to investigate the interaction of nanoparticles with the mucus as well as the novel developments of mucus penetrating nanoparticles. (c) 2015 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.
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