期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 11, 页码 2745-2749出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201806327
关键词
hemicalide; multistep synthesis; natural products; polyketides; stereochemistry
资金
- ANR [ANR-BLAN-2013]
- CNRS
A strategy for the assembly of the entire carbon backbone of a stereoisomer of the antitumor marine natural product hemicalide has been investigated. The devised convergent approach relies on Horner-Wadsworth-Emmons and Julia-Kocienski olefination reactions for the construction of the C6=C7 and C34=C35 double bonds, respectively, an aldol reaction to create the C27-C28 bond, and a Suzuki-Miyaura cross-coupling as the endgame to form the C15-C16 bond.
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