期刊
CELLS
卷 4, 期 2, 页码 178-201出版社
MDPI
DOI: 10.3390/cells4020178
关键词
Scavenger receptor; Oxidized LDL particle; Atherosclerosis; Signal transduction
类别
资金
- Brunei Government
- Circulation Foundation Clinician-Scientist Award
- British Heart Foundation
- Medical Research Council
- European Research Council fellowship
- British Heart Foundation [PG/12/56/29748, PG/09/054/27838] Funding Source: researchfish
Scavenger receptors (SRs) are a 'superfamily' of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. Their ability to bind a range of ligands is reflected on the biological functions such as clearance of modified lipoproteins and pathogens. SR members regulate pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer. Here, we review our current understanding of SR structure and function implicated in health and disease.
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