期刊
CELLS
卷 4, 期 3, 页码 297-314出版社
MDPI
DOI: 10.3390/cells4030297
关键词
Paramecium; cilia; calcium; signal transduction; swimming behavior; electrophysiology; proteomics
类别
资金
- IDeA from NIGMS of NIH [P20 GM103449]
- NIH from COBRE Program of the National Center for Research Resources [5 P30 RR032135]
- NIGMS [8 P30 GM103498]
Paramecium species, especially P. tetraurelia and caudatum, are model organisms for modern research into the form and function of cilia. In this review, we focus on the ciliary ion channels and other transmembrane proteins that control the beat frequency and wave form of the cilium by controlling the signaling within the cilium. We put these discussions in the context of the advantages that Paramecium brings to the understanding of ciliary motility: mutants for genetic dissections of swimming behavior, electrophysiology, structural analysis, abundant cilia for biochemistry and modern proteomics, genomics and molecular biology. We review the connection between behavior and physiology, which allows the cells to broadcast the function of their ciliary channels in real time. We build a case for the important insights and advantages that this model organism continues to bring to the study of cilia.
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