期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 22, 页码 5600-5610出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201805093
关键词
active matter; biophysics; liquid-liquid phase separation; membraneless organelles
资金
- US National Science Foundation [1818385]
- US NIGMS/NIH [RO1 GM066833, RO1 GM115634, R35 GM130375]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1818385] Funding Source: National Science Foundation
Compartmentalization of biochemical processes is essential for cell function. Although membrane-bound organelles are well studied in this context, recent work has shown that phase separation is a key contributor to cellular compartmentalization through the formation of liquid-like membraneless organelles (MLOs). In this Minireview, the key mechanistic concepts that underlie MLO dynamics and function are first briefly discussed, including the relevant noncovalent interaction chemistry and polymer physical chemistry. Next, a few examples of MLOs and relevant proteins are given, along with their functions, which highlight the relevance of the above concepts. The developing area of active matter and non-equilibrium systems, which can give rise to unexpected effects in fluctuating cellular conditions, are also discussed. Finally, our thoughts for emerging and future directions in the field are discussed, including in vitro and in vivo studies of MLO physical chemistry and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据