期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 17, 页码 4390-4397出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201805542
关键词
alkynyl ketones; asymmetric catalysis; Bronsted bases; Michael reaction; organocatalysis
资金
- University of the Basque Country UPV/EHU [UFI QOSYC 11/22]
- Basque Government (BG Grant) [IT-628-13]
- Ministerio de Economia y Competitividad (MINECO), Spain [CTQ2016-78487-C2]
- MINECO
- BG
Various sets of enolizable alkynyl ketones (including methyl ynones with alpha-aryl, alpha-alkenyl, and alpha-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Bronsted base/H-bond catalysts to provide adducts with two consecutive tertiary stereocenters in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic molecules, including some with intricate carbon skeletons, was also demonstrated.
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