期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 9, 页码 2217-2221出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201806159
关键词
alkyl oxamate; carbamoylation; C-H functionalization; heterocycles; photoredox catalysis
Nucleophilic radical additions at innately electrophilic C(sp(2)) centers are perfectly suited for the direct functionalization of heterocycles. Using bench stable and commercially available alkyl oxamate and oxamic acid derivatives in combination with photoredox catalysis, a direct carbamoylation of heterocycles yielding amide functionalized pharmacophores in a single step is reported. The reaction conditions reported are compatible with structurally complex heterocyclic substrates of pharmaceutical interest. Notably, derivatives containing functional groups incompatible with standard amidation reactions, such as carboxylic acids and unprotected amines, were found to be amenable to this reaction paradigm.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据