期刊
CHEMISTRY OF MATERIALS
卷 30, 期 22, 页码 8164-8169出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.8b02993
关键词
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资金
- National Science Foundation [CHE 1011796]
- Georgia Institute of Technology
- Children's Healthcare of Atlanta
Hyperbranched bicyclo[3.3.1]nonane (BCN) polycations were synthesized by the reaction of the bivalent electrophile thiabicyclo[3.3.1]nonane dinitrate with a series of simple tris(pyridine) nucleophiles, including one alkyne-containing nucleophile to allow for postpolymerization functionalization. The hyperbranched polymers were found to be efficient binders of nucleic acid and exhibited higher efficiencies for oligo DNA and siRNA transfection than their linear counterparts, enabling knockdown at low siRNA concentrations to a superior extent than standard hyper branched polyethylenimine and lipofectamine transfection agents. The use of an amide-containing linkage in the tris(pyridine) building block was found to be highly advantageous, but built-in fragmentability of the polycation structure, a unique potential feature of this new family of materials, did not give significantly better performance.
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