Photomodulated Nanozyme Used for a Gram-Selective Antimicrobial

Although broad-spectrum antibacterial agents have been developed for antibacterial treatment, the balance of microbial flora may break and this usually results in increasing resistance. To this end, developing simple and effective strain-selective bactericidal strategies are demanding. Herein we designed an intelligent Gram-selective antimicrobial system based on MoS2 and a photoacid molecule. This system can be modulated by light for surface charge conversion from negative to positive and simultaneously activation of the enzymatic activity of MoS2 by changing pH. In consideration of the different cell wall composition and structures of bacterial strains, Gram-selective antibacterial has been accomplished simply by controlling the light irradiation time. Taken together, we provided a simple and efficient photoregulated method to realize strain-selective antibacterial.