期刊
CHEMISTRY & BIODIVERSITY
卷 16, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201800424
关键词
Heracleum dissectum; folk herbs; polyacetylene glycosides; triglyceride accumulation; antidiabetic drugs; phytochemistry; biological activity
资金
- Natural Science Foundation of Shaanxi [2015JM8413]
- Natural Science Foundation of China [81673564]
Continually phytochemical study of the roots of Heracleum dissectum had led to the isolation of three previously undescribed polyacetylene glycosides (1-3), together with seven known compounds, including one polyacetylene (8) and six coumarins (4-7 and 9-10) using diverse chromatographic methods. The structures of these three new compounds were characterized and identified as deca-4,6-diyn-1-yl beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranosyl-(1 -> 2)-beta-d-glucopyranoside (1), (8Z)-dec-8-ene-4,6-diyn-1-yl beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranosyl-(1 -> 2)-beta-d-glucopyranoside (2), and (8E)-dec-8-ene-4,6-diyn-1-yl beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranosyl-(1 -> 2)-beta-d-glucopyranoside (3) based on their physicochemical properties and extensive analyses of various spectroscopic data. Their triglycerides accumulating activities were assayed and the results showed that the three new polyacetylene glycosides (1-3) exhibited triglyceride accumulating activities in 3T3-L1 adipocytes.
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