期刊
CHEMICAL REVIEWS
卷 119, 期 9, 页码 6184-6226出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.8b00460
关键词
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资金
- U.S. Department of Energy [DE-AC52-07NA27344 (LLNL-JRNL-755168)]
- Wellcome Trust
- BBSRC
- ERC Advanced Grant COMP-MICR-CROW-MEM
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Canada Research Chairs program
- Alberta Innovates Technology Futures Strategic Chair in (Bio)Molecular Simulation
- BBSRC [BB/R00126X/1] Funding Source: UKRI
- EPSRC [EP/R004722/1, EP/R029407/1] Funding Source: UKRI
Cell membranes contain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity needed to fulfill their key roles in cell functioning. The compositional complexity of cellular membranes gives rise to a heterogeneous lateral organization, which is still poorly understood. Computational models, in particular molecular dynamics simulations and related techniques, have provided important insight into the organizational principles of cell membranes over the past decades. Now, we are witnessing a transition from simulations of simpler membrane models to multicomponent systems, culminating in realistic models of an increasing variety of cell types and organelles. Here, we review the state of the art in the field of realistic membrane simulations and discuss the current limitations and challenges ahead.
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