期刊
SLEEP
卷 38, 期 12, 页码 1973-1980出版社
OXFORD UNIV PRESS INC
DOI: 10.5665/sleep.5252
关键词
obstructive sleep apnea; sympathetic nervous system; hypertension; continuous positive airway pressure; arterial blood pressure
资金
- National Institutes of Health, National Heart Lung and Blood Institute [HL81693]
- Regional Research Council [PHRC 2006]
- Agiradom
- ResMed
Study Objectives: To test the hypothesis that greater resting sympathetic activity in obstructive sleep apnea (OSA) syndrome would not induce a lesser sympathetic neurovascular transduction. Design: Case-controlled cohort study. Participants: 33 patients with newly diagnosed OSA without comorbidities and 14 healthy controls. Interventions: 6 months of continuous positive airway pressure (CPAP) treatment for OSA patients and follow-up for 9 healthy controls. Measurements and Results: We assessed resting sympathetic outflow and sympathetic neurovascular transduction. Sympathetic activity was directly measured (microneurography) at rest and in response to sustained isometric handgrip exercise. Neurovascular transduction was derived from the relationship of sympathetic activity and blood pressure to leg blood flow during exercise. Despite an elevated sympathetic activity of similar to 50% in OSA compared to controls, neurovascular transduction was not different (i.e., absence of tachyphylaxis). After six months of CPAP, there were significant declines in diastolic pressure, averaging similar to 4 mm Hg, and in sympathetic activity, averaging similar to 20% with no change in transduction. Conclusions: Greater sympathetic activity in obstructive sleep apnea does not appear to be associated with lesser neurovascular transduction. Hence, elevated sympathetic outflow without lesser transduction may underlie the prevalent development of hypertension in this population that is well controlled by continuous positive airway pressure treatment.
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