期刊
CHEMBIOCHEM
卷 20, 期 4, 页码 614-620出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800619
关键词
fluorescent probes; glycyrrhetinic acid; hepatocellular carcinoma; imaging agents; natural products
资金
- National Research Foundation of Korea [CRI 2018R1A3B1052702]
We report a glycyrrhetinic-acid (GA)-decorated small-molecule conjugate for pH-triggered near-infrared (NIR) fluorescence imaging of hepatocellular carcinoma (HCC). Our in vitro studies demonstrated that the conjugate, referred to as NIR-GA, was efficiently taken up by liver cancer cell lines such as HepG2 and Huh7 through an endocytic pathway mediated by GA receptors. As suggested by co-localization studies, NIR-GA mainly localized in the lysosome, where the acidic pH results in the activation of the fluorescent dye through H+-triggered spirolactam ring opening to give strong fluorescence in the NIR region.
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