期刊
CHEMBIOCHEM
卷 20, 期 1, 页码 83-87出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800592
关键词
biosynthesis; Gelsemium sempervirens; monoterpene indole alkaloid; strictosidine; synteny
资金
- DFG [FR 3720/1-1]
- BBSRC [BB/J009091/1]
- ERC [311363]
- Michigan State University Foundation
- European Research Council (ERC) [311363] Funding Source: European Research Council (ERC)
- BBSRC [BB/J009091/1] Funding Source: UKRI
Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information is not commonly used to identify novel biosynthesis genes. Here, we present the genome of the medicinal plant and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium sempervirens (Gelsemiaceae). A gene cluster from Catharanthus roseus, which is utilized at least six enzymatic steps downstream from the last common intermediate shared between the two plant alkaloid types, is found in G. sempervirens, although the corresponding enzymes act on entirely different substrates. This study provides insights into the common genomic context of MIA pathways and is an important milestone in the further elucidation of the Gelsemium oxindole alkaloid pathway.
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