期刊
CHEMBIOCHEM
卷 20, 期 9, 页码 1105-1114出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800721
关键词
biotechnology; chemical reaction networks; DNA; DNA recognition; strand-displacement reactions
资金
- National Science Foundation of China [21722502, 21505045, 21804091]
Motivated by complex molecular networks of biological organisms, which enable control of the temporal and spatial concentrations of molecules, the bottom-up development of artificial chemical reaction networks has received renewed interest from biochemists. Based on hybridization and strand-displacement reactions, DNA-based chemical reaction networks (D-CRNs) provide a promising method to describe and analyze (bio)chemical systems, depending on their high programmability and directionality. Herein, progress in the development of D-CRNs is discussed, and an overview of significant biochemistry applications based on D-CRNs reported in recent decades is provided. Furthermore, opportunities and future directions for research into D-CRNs in biochemistry are also discussed.
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