期刊
CHEMBIOCHEM
卷 20, 期 6, 页码 737-746出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800569
关键词
biomimetic synthesis; drug delivery; growth factors; polysaccharides; sulfur
资金
- China Scholarship Council
- Deutsche Forschungsgemeinschaft (DFG) [GR1290/12-1, ZH546/3-1]
Artificially sulfated polysaccharides, as the mimetics of native heparin and heparan sulfate, are important bioactive compounds, since they show great potential for tuning crucial biological activities within living organisms. Herein, we summarize progress in the development of artificially sulfated polysaccharides, such as cellulose sulfate, chitosan sulfate, and other sulfated polysaccharides, with a particular focus on the fields of biomedical and bioengineering applications in the past ten years. Their effects on cell growth and differentiation, but also as building blocks for drug carriers and medical implants, are emphasized.
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