期刊
CHEMBIOCHEM
卷 20, 期 12, 页码 1479-1486出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800715
关键词
dual-functional RNA; mRNA; ribosomally synthesised and post-translationally modified peptides; small-ORF-encoded peptides; proteomics
资金
- Deutsche Forschungsgemeinschaft (DFG) [SCHN 1273/3, GRK 2062]
- Center for Integrated Protein Science Munich (CIPSM) [EXC114]
Genetically encoded and ribosomally synthesised peptides and small proteins act as important regulators in fundamental cellular processes, including gene expression, development, signalling and metabolism. Moreover, they also play a crucial role in eukaryotic and prokaryotic defence against microorganisms. Extremely diverse in size and structure, they are often subject to extensive post-translational modification. Recent technological advances are now allowing the analysis of the whole cellular transcriptome and proteome, revealing the presence of hundreds of long-overlooked alternative and short open reading frames (short ORFs, or sORFs) in mRNA and supposedly noncoding RNAs. However, in many instances the biological roles of their translational products remain to be elucidated. Here we provide an overview on the intriguing structural and functional diversity of ribosomally synthesised peptides and newly discovered peptides and small proteins.
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