期刊
CEREBRAL CORTEX
卷 29, 期 10, 页码 4050-4066出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy284
关键词
astrocyte motility; astrocytes; intermediate filaments; mouse; nanofilaments; nestin; neural stem cells
资金
- Swedish Medical Research Council [2017-02255]
- ALF Gothenburg [146051]
- AFA Research Foundation
- Soderbergs Foundations
- Sten A. Olsson Foundation for Research and Culture
- Hjarnfonden
- Hagstromer's Foundation Millennium
- Amlov's Foundation
- E. Jacobson's Donation Fund
- VINNOVA
- Swedish Stroke Foundation
- Slovenian Research Agency Core Program Cell Physiology [P3 310, J3-6790, J3-7605]
- NanoNet COST Action [BM1002]
- EuroCellNet COST Action
- EU FP 7 Program EduGlia [237956]
- EU FP 7 Program TargetBraIn [279017]
- Swedish Research Council [2017-02255] Funding Source: Swedish Research Council
The intermediate filament (nanofilament) protein nestin is a marker of neural stem cells, but its role in neurogenesis, including adult neurogenesis, remains unclear. Here, we investigated the role of nestin in neurogenesis in adult nestin-deficient (Nes(-/-)) mice. We found that the proliferation of Nes(-/-) neural stem cells was not altered, but neurogenesis in the hippocampal dentate gyrus of Nes(-/-) mice was increased. Surprisingly, the proneurogenic effect of nestin deficiency was mediated by its function in the astrocyte niche. Through its role in Notch signaling from astrocytes to neural stem cells, nestin negatively regulates neuronal differentiation and survival; however, its expression in neural stem cells is not required for normal neurogenesis. In behavioral studies, nestin deficiency in mice did not affect associative learning but was associated with impaired long-term memory.
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