期刊
CANCERS
卷 7, 期 4, 页码 2466-2485出版社
MDPI
DOI: 10.3390/cancers7040904
关键词
cancer; oncogenic miRNAs; cell cycle regulation; apoptosis
类别
资金
- AIRC [14455]
- Epigen [13/05/R/42]
MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.
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