期刊
CELLULAR SIGNALLING
卷 53, 期 -, 页码 212-223出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2018.10.005
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资金
- Deutsche Forschungsgemeinschaft (DFG Research Unit 2407) [JE 642/4-1]
- European Community's Seventh Framework Programme [602300]
- Deutsche Forschungsgemeinschaft (DFG Research Unit 2722)
Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In most cases, OA is associated with a variable degree of synovial inflammation. A variety of different cell types including chondrocytes, synovial fibroblasts, adipocytes, osteoblasts and osteoclasts as well as stem and immune cells are involved in catabolic and inflammatory processes but also in attempts to counteract the cartilage loss. At the molecular level, these changes are regulated by a complex network of proteolytic enzymes, chemokines and cytokines (for review: [1]). Here, interleukin-1 signaling (IL-1) plays a central role and its effects on the different cell types involved in OA are discussed in this review with a special focus on the chondrocyte.
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