期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 6, 页码 1107-1134出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2984-8
关键词
Adipocyte; Aging; Airway hypersensitivity; Apoptosis; Autophagy; Cancer; Cardiomyopathy; Ceramide; Ceramide synthase; Dihydroceramide desaturase 1-Des-1; Diabetes; Dihydrosphinganine; FB1 toxicity; Hypoxia; Neurodegenerative; Sphingosine kinase; Serine palmitoyl transferase; Sphingosine-1-phosphateS1P; Sphingosine-1-phosphate receptors; 4-HRP fenretinide
资金
- National Health and Medical Research Council of Australia [1092642, 1087355]
- Monash Graduate Scholarship
- Monash International Postgraduate Research Scholarship
- National Health and Medical Research Council of Australia [1087355] Funding Source: NHMRC
Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10-15years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest.
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