期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 3, 页码 505-521出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2945-2
关键词
Stem cell differentiation; Musculoskeletal system; Topography; Tissue engineering
资金
- National key R&D program of China [2017YFA0104901, 2017YFA0104900]
- National key research and development program of China [2016YFC1100204]
- NSFC [81572115, 81874019, 81572157, 81330041, 81125014, 31271041, 81201396, 81271970, J1103603, 81522029, 31570987, 81401781]
- Regenerative Medicine in Innovative Medical Subjects of Zhejiang Province
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents, Zhejiang Province [Z2100086, LY12H06006, LR14H060001, LY14H060003]
- Key scientific and technological innovation team of Zhejiang Province [2013TD11]
- Medical and Health Science and Technology Plan of the Department of Health of Zhejiang Province [2013RCA010, 2014KYB052]
- Medical Science and Technology Project of Zhejiang Province [201341741]
- Zhejiang Provisional Grant [2012C33015]
- International Science and Technology Cooperation Program of China [2015DFG32130]
- Fundamental Research Funds for the Central Universities
It is well known that biomaterial topography can exert a profound influence on various cellular functions such as migration, polarization, and adhesion. With the development and refinement of manufacturing technology, much research has recently been focused on substrate topography-induced cell differentiation, particularly in the field of tissue engineering. Even without biological and chemical stimuli, the differentiation of stem cells can also be initiated by various biomaterials with different topographic features. However, the underlying mechanisms of this biological phenomenon remain elusive. During the past few decades, many researchers have demonstrated that cells can sense the topography of materials through the assembly and polymerization of membrane proteins. Following the activation of RHO, TGF-b or FAK signaling pathways, cells can be induced into various differentiation states. But these signaling pathways often coincide with canonical mechanical transduction pathways, and no firm conclusion has been reached among researchers in this field on topography-specific signaling pathways. On the other hand, some substrate topographies are reported to have the ability to inhibit differentiation and maintain the stemness' of stem cells. In this review, we will summarize the role of topography in musculoskeletal system regeneration and explore possible topography-related signaling pathways involved in cell differentiation.
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