期刊
CELL STEM CELL
卷 24, 期 1, 页码 41-53出版社
CELL PRESS
DOI: 10.1016/j.stem.2018.12.009
关键词
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资金
- NCATS NIH HHS [TL1 TR002549] Funding Source: Medline
- NCI NIH HHS [R35 CA197718, R01 CA184090, F30 CA217066, R01 CA171652, R01 CA116659, R01 CA154130, R01 CA169117, R01 CA129958] Funding Source: Medline
- NIGMS NIH HHS [F32 GM019132, T32 GM007250] Funding Source: Medline
- NINDS NIH HHS [K02 NS047409, R01 NS070315, R01 NS054276, R01 NS087913, R01 NS099175, R01 NS103434, R01 NS089272, R01 NS091080] Funding Source: Medline
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor components have multi-directional interactions involving CSCs, supporting the complexity of tumors to maintain growth in a dynamic host. In this Perspective, we discuss how CSCs are active architects of their microenvironment and drive interactions with other tumor components, such as immune cells, cancer-associated fibroblasts and differentiated cells, blood vessels, and other extracellular cues to engineer a sustainable niche. We also highlight considerations for modeling this dynamic tumor ecology and discuss potential therapeutic strategies for targeting these multifaceted interactions.
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