相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Hayley J. Sharpe et al.
CANCER CELL (2015)
Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer
Zhao-Heng Duan et al.
CANCER SCIENCE (2015)
p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling
Elisa Maria Memmi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
Yen-Hsing Li et al.
CELL REPORTS (2015)
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma
S. N. Brun et al.
ONCOGENE (2015)
Molecular Subgrouping of Medulloblastoma: Impact Upon Research and Clinical Practice
Tejpal Gupta et al.
CURRENT PEDIATRIC REVIEWS (2015)
International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading
David N. Louis et al.
BRAIN PATHOLOGY (2014)
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Marcel Kool et al.
CANCER CELL (2014)
Management of Pediatric and Adult Patients with Medulloblastoma
Allison M. Martin et al.
CURRENT TREATMENT OPTIONS IN ONCOLOGY (2014)
Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors
Antoine Forget et al.
DEVELOPMENTAL CELL (2014)
The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors
Frederic Mille et al.
DEVELOPMENTAL CELL (2014)
The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma
Qiuran Xu et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)
Cytogenetic Prognostication Within Medulloblastoma Subgroups
David J. H. Shih et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma
Xuelian He et al.
NATURE MEDICINE (2014)
T-cell TGF-β signaling abrogation restricts medulloblastoma progression
David Gate et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
PKM2 regulates Glil expression in hepatocellular carcinoma
Qiuran Xu et al.
ONCOLOGY LETTERS (2014)
GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study
A. Italiano et al.
ANNALS OF ONCOLOGY (2013)
Canonical TGF-β Pathway Activity Is a Predictor of SHH-Driven Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development
Donya Aref et al.
BRAIN PATHOLOGY (2013)
Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study
Amar Gajjar et al.
CLINICAL CANCER RESEARCH (2013)
Hedgehog Signaling Pathway Regulates Autophagy in Human Hepatocellular Carcinoma Cells
Ying Wang et al.
HEPATOLOGY (2013)
Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
Nataliya Zhukova et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Dereck Amakye et al.
NATURE MEDICINE (2013)
Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma
B. A. Emmenegger et al.
ONCOGENE (2013)
Isolated Sensorineural Hearing Loss as Initial Presentation of Recurrent Medulloblastoma: Neuroimaging and Audiologic Correlates
C. S. Amene et al.
CLINICAL NEURORADIOLOGY (2013)
Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma
Pritha Paul et al.
ONCOTARGET (2013)
Early morning headache with vomiting in a 5 year old boy
Benjamin R. T. Jones et al.
BMJ-BRITISH MEDICAL JOURNAL (2013)
Molecular subgroups of medulloblastoma: the current consensus
Michael D. Taylor et al.
ACTA NEUROPATHOLOGICA (2012)
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool et al.
ACTA NEUROPATHOLOGICA (2012)
The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
Yan Wang et al.
CANCER CELL (2012)
CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog-Driven Medulloblastoma
Rajarshi Sengupta et al.
CANCER RESEARCH (2012)
A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission
Stanley B. Kaye et al.
CLINICAL CANCER RESEARCH (2012)
Identification of N-terminal Residues of Sonic Hedgehog Important for Palmitoylation by Hedgehog Acyltransferase
Rayshonda Y. Hardy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A Distinct Smoothened Mutation Causes Severe Cerebellar Developmental Defects and Medulloblastoma in a Novel Transgenic Mouse Model
Joyoti Dey et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
Jean Y. Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Aleksandar Sekulic et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
Michelle J. Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Hedgehog pathway as a drug target: Smoothened inhibitors in development
Tara L. Lin et al.
ONCOTARGETS AND THERAPY (2012)
Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
Tapati Mazumdar et al.
CANCER RESEARCH (2011)
Challenging issues in pediatric oncology
Ching-Hon Pui et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation
Reem Malek et al.
PLOS ONE (2011)
Cyclic AMP Suppression Is Sufficient to Induce Gliomagenesis in a Mouse Model of Neurofibromatosis-1
Nicole M. Warrington et al.
CANCER RESEARCH (2010)
Identification of a Suppressive Mechanism for Hedgehog Signaling through a Novel Interaction of Gli with 14-3-3
Yoshinari Asaoka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The primary cilium at a glance
Peter Satir et al.
JOURNAL OF CELL SCIENCE (2010)
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors
Thomas C. Whisenant et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
Pediatric medulloblastoma: Toxicity of current treatment and potential role of protontherapy
Piero Fossati et al.
CANCER TREATMENT REVIEWS (2009)
Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation
Y. Katoh et al.
CURRENT MOLECULAR MEDICINE (2009)
Protein Kinase Cδ Negatively Regulates Hedgehog Signaling by Inhibition of Gli1 Activity
Qingsong Cai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
Charles M. Rudin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Joel M. Hyman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch et al.
SCIENCE (2009)
The Smo/Smo model: Hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
Beryl A. Hatton et al.
CANCER RESEARCH (2008)
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
N. Spassky et al.
DEVELOPMENTAL BIOLOGY (2008)
Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy
Chinatsu Kasuga et al.
JOURNAL OF NEUROSURGERY-PEDIATRICS (2008)
Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective
Judith M. de Bont et al.
NEURO-ONCOLOGY (2008)
Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the Hedgehog signaling antagonist cyclopamine in the mouse
Robert J. Lipinski et al.
TOXICOLOGICAL SCIENCES (2008)
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
Maarten F. Bijlsma et al.
CELLULAR SIGNALLING (2007)
Lipoprotein-heparan sulfate interactions in the Hh pathway
Christina Eugster et al.
DEVELOPMENTAL CELL (2007)
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Matthias Lauth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
Zhenyu Ji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Melanomas require HEDGEHOG-GLI signaling reaulated by interactions between GLI1 and the RAS-MEK/AKT pathways
Barbara Stecca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
Marie P. Fogarty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structural, functional and therapeutic biology of survivin
N. K. Sah et al.
CANCER LETTERS (2006)
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
Marina Pasca di Magliano et al.
GENES & DEVELOPMENT (2006)
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
Y Pan et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Inhibition of GLI1 gene activation by patched1
F Rahnama et al.
BIOCHEMICAL JOURNAL (2006)
Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
T Sheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Gli1 is important for medulloblastoma formation in Ptc1+/- mice
H Kimura et al.
ONCOGENE (2005)
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
P Sanchez et al.
MECHANISMS OF DEVELOPMENT (2005)
Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
W Chen et al.
SCIENCE (2004)
Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling
I Rios et al.
DEVELOPMENT (2004)
Inhibition of Smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
M Athar et al.
CANCER RESEARCH (2004)
Suppressor of fused regulates Gli activity through a dual binding mechanism
M Merchant et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Delay in the diagnosis of paediatric brain tumours
M Dobrovoljac et al.
EUROPEAN JOURNAL OF PEDIATRICS (2002)
Mutations in SUFU predispose to medulloblastoma
MD Taylor et al.
NATURE GENETICS (2002)
Hedgehog signaling in animal development: paradigms and principles
PW Ingham et al.
GENES & DEVELOPMENT (2001)
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale et al.
NATURE (2000)