期刊
CELL METABOLISM
卷 29, 期 2, 页码 269-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2018.09.021
关键词
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资金
- Cancer Research UK core fund through the CRUK Beatson Institute [A17196]
- CRUK Career Development Fellowship [C53309/A19702]
- ERC H2020 Marie Sklodowska Curie Actions Individual Fellowship [705190]
- British Lung Foundation [CSOBLF16-2]
- Wellcome Trust
- Royal Society [104103/Z/14/Z]
- Marie Curie Actions (MSCA) [705190] Funding Source: Marie Curie Actions (MSCA)
The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges. The mechanisms driving such programs are largely unknown. Here, we show that enteroendocrine cells in the adult Drosophila intestine respond to nutrients by secreting the hormone Bursicon alpha, which signals via its neuronal receptor DLgr2. Bursicon alpha/DLgr2 regulate energy metabolism through a neuronal relay leading to the restriction of glucagon-like, adipokinetic hormone (AKH) production by the corpora cardiaca and subsequent modulation of AKH receptor signaling within the adipose tissue. Impaired Bursicon alpha/DLgr2 signaling leads to exacerbated glucose oxidation and depletion of energy stores with consequent reduced organismal resistance to nutrient restrictive conditions. Altogether, our work reveals an intestinal/neuronal/adipose tissue inter-organ communication network that is essential to restrict the use of energy and that may provide insights into the physiopathology of endocrine-regulated metabolic homeostasis.
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