期刊
CELL DEATH AND DIFFERENTIATION
卷 26, 期 7, 页码 1181-1194出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41418-018-0231-3
关键词
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资金
- national Key R&D project of the Chinese Ministry of Science and Technology [2016YFC0904600]
- Key Program of the National Natural Science Foundation of China [U1432248, U1632270]
- National Natural Science Foundation of China [11675234, 11575262]
- Affinomics consortium - European Union [Health-F4-2010-241481]
- Natural Science Foundation of Gansu [17JR5RA310]
Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy.
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