期刊
CELL
卷 175, 期 3, 页码 605-614出版社
CELL PRESS
DOI: 10.1016/j.cell.2018.07.044
关键词
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资金
- Ligue contre le Cancer
- Agence National de la Recherche (ANR)
- Canceropole Ile-de-France
- Chancelerie des universites de Paris (Legs Poix)
- European Commission (ArtForce)
- European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
- Fondation Carrefour
- Institut National du Cancer (INCa)
- Inserm (HTE)
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumiere
- Seerave Foundation
- SIRICs SOCRATE
- CARPEM
- European Research Council (DeAge)
- Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (Ciberonc)
- Progeria Research Foundation
- Austrian Science Fund FWF (Austria) [P23490-B20, P29262, P24381, P29203, P27893]
- DKplus Metabolic and Cardiovascular Diseases [W1226]
- Bundesministerium fur Wissenschaft, Forschung und Wirtschaft
- Karl-Franzens University
- NAWI Graz
- Bio-TechMed-Graz flagship project EPIAge
- National Institute on Aging, NIH
Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as carbotoxicity.'' Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as well as the beneficial effects of reducing carbs in the diet. We discuss the molecular, cellular, and neuroendocrine mechanisms that link exaggerated carbohydrate intake to disease and accelerated aging as we outline dietary and pharmacologic strategies to combat carbotoxicity.
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