4.3 Article

Monitoring of Thermal-Induced Changes in Liver Stiffness During Controlled Hyperthermia and Microwave Ablation in an Ex Vivo Bovine Model Using Point Shear Wave Elastography

期刊

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
卷 42, 期 5, 页码 744-750

出版社

SPRINGER
DOI: 10.1007/s00270-018-02152-y

关键词

Thermal ablation; Shear wave velocity; Elastosonography; Liver tissue; Microwave; Stiffness

向作者/读者索取更多资源

PurposeTo investigate liver stiffness changesevaluated by point shear wave elastography (pSWE)in controlled hyperthermia and microwave ablation (MWA) in an ex vivo animal model.Materials and MethodsFive samples of ex vivo bovine liver were uniformly heated to temperatures ranging from 40 to 100 degrees C. B-mode ultrasound imaging and pSWE were acquired simultaneously, and shear wave velocity (SWV) was measured in a region of interest (ROI). The threshold value of SWV at 60 degrees C (avg60) was identified. Subsequently, MWA was performed in 11 liver samples at 60W until avg60+0.5m/s was reached. SWV was measured in ROIs at 10-40mm from the antenna feed. The correlation of mean values of SWV with location (within, border, or outside necrotic area) at gross pathology was evaluated.ResultsIn controlled hyperthermia experiments, a steep transition in liver stiffness was observed at 63.02.4 degrees C (SWV 3.54 +/- 0.68m/s). Avg60 was of 2.5m/s. In 8/9 MWA experiments, interrupted when SWV of 3m/s was measured, the ROI was at the inner side of the necrotic area border at pathology (accuracy 89%). No correlation between SWV values for outside, border, and within necrosis could be identified.Conclusionsp id=Par4pSWE can provide a velocity threshold predictive of the presence of coagulation necrosis during MWA in ex vivo liver model. However, pSWE is not able to reliably capture changes in stiffness within, at the border, and outside the necrotic zone in this experimental model.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据