期刊
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
卷 96, 期 12, 页码 1318-1327出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjpp-2018-0227
关键词
AuNPs; myocardial infarction; cardiac fibrosis; inflammation
资金
- National Basic Research Program of China [2014CBA02000]
- National Natural Science Foundation of China [81820108031, 81471893, 81270157, 91539123, 81070078]
- Beijing Municipal Natural Science Foundation [7172235]
Gold nanoparticles (AuNPs) are widely used for drug delivery because of their unique biological properties, such as their safety and ability to prolong drug action. Some studies have demonstrated that AuNPs accumulate in the heart, especially during pathological processes. Therefore, it is very important to understand the effect of AuNPs on the heart. Myocardial infarction (MI) is a major cause of morbidity and mortality; however, the effect of AuNPs on MI remains unclear. In the present study, we carried out a comprehensive evaluation of AuNPs on acute MI. The results showed that AuNPs accumulated in infarcted hearts, decreased infarction size, improved systolic function, and inhibited cardiac fibrosis and TNF-alpha accumulation. Our work indicated that AuNPs have cardioprotective effects and can be used in drug delivery systems for the treatment of cardiac diseases.
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