期刊
EBIOMEDICINE
卷 2, 期 10, 页码 1549-1558出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2015.07.029
关键词
Centenarian; Ageing; Inflammation; Telomere
资金
- BBSRC [BB/I020748/1] Funding Source: UKRI
- MRC [G0601333] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I020748/1] Funding Source: Medline
- Medical Research Council [G0601333] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/I020748/1] Funding Source: researchfish
- Medical Research Council [G0601333] Funding Source: researchfish
To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99 years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains. In Cox proportional hazard models, inflammation predicted all-cause mortality with hazard ratios (95% CI) 1.89 (1.21 to 2.95) and 1.36 (1.05 to 1.78) in the very old and (semi-)supercentenarians, respectively. In linear forward stepwise models, inflammation predicted capability (10.8% variance explained) and cognition (8.6% variance explained) in (semi-) supercentenarians better than chronologic age or gender. The inflammation score was also lower in centenarian offspring compared to age-matched controls with. (95% CI) = -0.795 (-1.436 to -0.154). Centenarians and their offspring were able to maintain long telomeres, but telomere length was not a predictor of successful ageing in centenarians and semi-supercentenarians. We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans. Crown Copyright (C) 2015 Published by Elsevier B.V.
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