期刊
BRITISH JOURNAL OF RADIOLOGY
卷 92, 期 1096, 页码 -出版社
BRITISH INST RADIOLOGY
DOI: 10.1259/bjr.20180601
关键词
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资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01 EB003268]
- Canadian Institutes of Health Research [MOP 119312, FDN 154272]
- W. Garfield Weston Foundation
- Canada Research Chairs program
Transcranial focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase blood-brain barrier permeability to enable targeted drug delivery to the central nervous system, and is a technique that has the potential to revolutionize the way neurological diseases are managed in medical practice. Clinical testing of this approach is currently underway in patients with brain tumors, early Alzheimer's disease, and amyotrophic lateral sclerosis. A major challenge that needs to be addressed in order for widespread clinical adoption of FUS-mediated blood-brain barrier permeabilization to occur is the development of systems and methods for real-time treatment monitoring and control, to ensure that safe and effective acoustic exposure levels are maintained throughout the procedures. This review gives a basic overview of the oscillation dynamics, acoustic emissions, and biological effects associated with ultrasound-stimulated microbubbles in vivo, and provides a summary of recent advances in acoustic-based strategies for detecting, controlling, and mapping microbubble activity in the brain. Further development of next-generation clinical FUS brain devices tailored towards microbubble-mediated applications is warranted and required for translation of this potentially disruptive technology into routine clinical practice.
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