期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 184, 期 1, 页码 45-59出版社
WILEY
DOI: 10.1111/bjh.15614
关键词
classical Hodgkin lymphoma; nodular lymphocyte predominant Hodgkin lymphoma; T-cell/histiocyte-rich large B-cell lymphoma; grey zone lymphoma; Epstein Barr virus
类别
资金
- Intramural Research Budget of the Center for Cancer Research, National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZIEBC011241] Funding Source: NIH RePORTER
The Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms now considered to be of B-cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an eponym that encompasses multiple entities. One of the unifying themes is the major contribution from the tumour microenvironment. Both the character of the neoplastic cells and the nature of the immune environment are critical to accurate diagnosis. Moreover, an understanding of the molecular alterations that characterize both the neoplastic cells and their microenvironment have led to therapeutic advances, targeting both neoplastic and reactive components. Other conditions may foster a similar inflammatory milieu and lead to lymphoproliferations that mimic the Hodgkin lymphomas. In this review we provide an update on the diagnostic features of the various subtypes and include additional information relevant for prognostic evaluation and investigation of potential therapeutic targets. Additionally, we also discuss those conditions that often cause confusion in diagnosis and need to be distinguished from the Hodgkin lymphomas.
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