期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 77, 期 -, 页码 77-91出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2018.12.008
关键词
Arcuate nucleus; Cx3cr1-Dir rat; Energy expenditure; Ghrelin; Hypothalamus; Inflammation; Leptin; Microglia; Neuropeptide Y; Paraventrlcular thalamic nucleus; Satiety
资金
- National Health and Medical Research Centre Career Development Fellowship II [APP1128646]
- RMIT University PhD Scholarship
- RMIT University
Microglia are highly sensitive to dietary influence, becoming activated acutely and long-term by high fat diet. However, their role in regulating satiety and feeding in healthy individuals remains unclear. Here we show that microglia are essential for the normal regulation of satiety and metabolism in rats. Short-term microglial depletion in a Cx3cr1-Dir rat led to a dramatic weight loss that was largely accounted for by an acute reduction in food intake. This weight loss and anorexia were not likely due to a sickness response since the rats did not display peripheral or central inflammation, withdrawal, anxiety-like behavior, or nausea-associated pica. Hormonal and hypothalamic anatomical changes were largely compensatory to the suppressed food intake, which occurred in association with disruption of the gustatory circuitry at the paraventricular nucleus of the thalamus. Thus, microglia are important in supporting normal feeding behaviors and weight, and regulating preference for palatable food. Inhibiting this circuitry is able to over-ride strong compensatory drives to eat, providing a potential target for satiety control.
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