期刊
BONE
卷 120, 期 -, 页码 523-532出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2018.10.004
关键词
Epigenetics; Endochondral ossification; Gene regulation; Cartilage; Chondrogenesis; DNA methylation; Histone methylation; lncRNA; miRNA
资金
- Agence Nationale de la Recherche, France [ANR-15-CE14-0002-01]
- Region Normandie, France
- European Union, France [FEDER/FSE] [2014-2020 - 16E00779/16P03685]
- Societe Francaise de Rhumatologie, France (SFR)
Within the last decade epigenetics has emerged as fundamental regulator of numerous cellular processes, including those orchestrating embryonic and fetal development. As such, epigenetic factors play especially crucial roles in endochondral ossification, the process by which bone tissue is created, as well during articular cartilage formation. In this review, we summarize the recent discoveries that characterize how DNA methylation, histone post-translational modifications and non-coding RNA (e.g., miRNA and lcnRNA) epigenetically regulate endochondral ossification and chondrogenesis.
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