期刊
JOURNAL FOR IMMUNOTHERAPY OF CANCER
卷 3, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s40425-015-0094-9
关键词
Indoleamine 2,3-dioxygenase; IDO inhibitors; Immune surveillance; Immunomodulatory; Malignancy
Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据