期刊
BMC INFECTIOUS DISEASES
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12879-018-3429-6
关键词
Respiratory tract infections; FilmArray respiratory panel; Respiratory organisms; Children
资金
- Key Developing Disciplines Project from Shanghai Municipal Commission of Health and Family Planning [2016ZB0104]
- Collaborative Innovation Center for Translational Medicine at Shanghai Jiaotong University School of Medicine [TM201616]
- Love Charity Foundation Research Project in Shanghai Children's Medical Center [2017SCMC-AY004]
Background: Respiratory tract infections (RTIs) are the most common illness in children, and rapid diagnosis is required for the optimal management of RTIs, especially severe infections. Methods: Nasopharyngeal swab or sputum specimens were collected from children aged 19 days to 15 years who were admitted to a hospital in Shanghai and diagnosed with RTIs. The specimens were tested with the FilmArray Respiratory Panel, a multiplex PCR assay that detects 16 viruses, Mycoplasma pneumoniae (M. pneumoniae), Bordetella pertussis (B. pertussis) and Chlamydophila pneumoniae (C. pneumoniae). Results: Among the 775 children studied, 626 (80.8%, 626/775) tested positive for at least one organism, and multiple organisms were detected in 198 (25.5%). Rhinoviruses/enteroviruses (25.5%, 198/775) were detected most often, followed by respiratory syncytial virus (19.5%, 151/775), parainfluenza virus 3 (14.8%, 115/775), influenza A or B (10.9%), adenovirus (10.8%), M. pneumoniae (10.6%) and B. pertussis (6.3%). The prevalence of organisms differed by age, and most of the viruses were more common in winter. Of the 140 children suspected of having pertussis, 35.0% (49/140) tested positive for B. pertussis. Conclusions: FilmArray RP allows the rapid simultaneous detection of a wide number of respiratory organisms, with limited hands-on time, in Chinese pediatric patients with RTIs.
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