期刊
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12906-018-2420-5
关键词
Tongbi-san; High-fat diet; Adipogenesis; Obesity; AMPK
资金
- Basic Science Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1D1A1B03034167]
BackgroundRecently, it has been noted that natural herbal medications may be effective in treating obesity. Tongbi-san (TBS) is a traditional medicine usually used for dysuria (i.e., painful urination), containing three herbs, Cyperus rotundus L., Citrus unshiu Markovich, and Poria cocos. In this study, we aimed to examine whether TBS can inhibit high-fat diet (HFD)-induced adipogenesis in the liver and epididymal adipose tissue of obese mice.MethodsMale C57BL/6N mice were fed a normal diet, an HFD, an HFD plus orlistat 10 or 20mg/kg, or an HFD plus TBS 50 or 100mg/kg for 11weeks. Body weight was checked weekly and histological tissue examinations were investigated. An expression of genes involved in adipogenesis was also assessed.ResultsOral administration of TBS significantly reduced body weight and decreased epididymal and visceral white adipose tissue (WAT) weight. In addition, we found that TBS enhanced the expression of the adenosine monophosphate-activated protein kinase (AMPK) and inhibited the expression of transcription factors, such as CCAAT/enhancer-binding proteins (C/EBPs), sterol regulatory element-binding protein 1 (SREBP1), and peroxisome proliferator-activated receptor (PPAR) in the liver and epididymal WAT as measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR).ConclusionThese findings demonstrate that the anti-obesity effects of TBS may be linked to the activation of AMPK.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据