期刊
BMC CANCER
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12885-018-5249-x
关键词
Helicobacter pylori; oipA; cagA; vacA; Gastric cancer
类别
资金
- Fundacao Cearense a Pesquisa (FUNCAP)
- CNPq (Brazilian National Council of Research)
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais -Brazil)
BackgroundAlthough, outer membrane protein OipA of Helicobacter pylori has been associated with gastric mucosal damage and gastroduodenal diseases, studies evaluating gastric cancer patients are scarce. We investigated whether the functional oipA on status was associated with gastric cancer in the North-eastern Brazil, region with high prevalence of gastric cancer.MethodsWe included samples from 95 H. pylori positive subjects (23 patients with gastritis, 24 with gastric cancer, 32 first-degree relatives of gastric cancer patients and 16 children). oipA was assayed by polymerase chain reaction (PCR) and DNA sequencing. cagA and vacA status were evaluated by PCR.ResultsOverall 81.1% of the H. pylori strains had functional oipA. In adults, the oipA on status (OR=9.20; 95%CI=1.45-58.48, P=0.02) and increasing age (OR=1.08; 95%CI=1.03-1.14; P=0.003) were independently associated with gastric cancer in a logistic model. The oipA on status (OR=14.75; 95%CI: 2.53-86.13, P=0.003) was also associated with first-degree relatives of gastric cancer patients when compared with gastritis. The frequency of oipA on status did not differ between children and adults (P=0.87). The oipA on status was significantly correlated with the presence of cagA and vacA s1m1.ConclusionoipA on status was independently associated with gastric cancer and first-degree relatives of gastric cancer patients in North-eastern Brazil.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据