期刊
BMC BIOINFORMATICS
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12859-018-2493-7
关键词
Protein-protein interactions; Mutants; Kinetic data; Thermodynamic data
类别
资金
- National Natural Science Foundation of China [61672035, 61300058, 61472282, 61872004]
BackgroundProtein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years.ResultsTo address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and network map construction, can be performed online.ConclusionOur work can promote the study on PPIs, and novel information can be mined from the new database. Our database is available in http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ for use by all, including both academics and non-academics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据