期刊
BIOTECHNOLOGY ADVANCES
卷 37, 期 1, 页码 68-90出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.11.006
关键词
Antipathogens; Aquaculture; Biofilm; Human health; Infectious diseases; Inhibitors; Pathogens; Quorum sensing
资金
- Brain Pool grant by National Research Foundation of Korea (NRF) [NRF-2018H1D3A2001746]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2017R1A2B3011676, 2017R1A4A1014806]
- Intelligent Synthetic Biology Center of Global Frontier Project through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2013M3A6A8073184]
- National Research Foundation of Korea [2018H1D3A2001746, 22A20130012144, 2011-0031957] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through QS regulation. The major issue to arise from such networks is increased bacterial resistance to antibiotics, resulting from QS-dependent mediation of the formation of biofilm, the induction of efflux pumps, and the production of antibiotics. QS inhibitors (QSIs) of diverse origins have been shown to act as potential antipathogens. In this review, we focus on the use of QSIs to counter diseases in humans as well as plants and animals of economic importance. We also discuss the challenges encountered in the potential applications of QSIs.
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