期刊
BIOTECHNOLOGY ADVANCES
卷 37, 期 1, 页码 132-144出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.11.009
关键词
Histone; Transfection; Gene therapy; Fusion protein; Synergistic effects
资金
- National Key R&D Program of China [2018YFC1105400]
- National Natural Science Foundation of China [81473142, 81673502, 81872928]
- Province University Cooperation Project of Jilin Province [SXGJQY2017-4]
- Education Department of Jilin Province [JJKH20180245KJ]
- Graduate Innovation Program of Jilin University [2016149, 2017058]
Histone has been considered to be an effective carrier in non-viral gene delivery due to its unique properties such as efficient DNA binding ability, direct translocation to cytoplasm and favorable nuclear localization ability. Meanwhile, the rapid development of genetic engineering techniques could facilitate the construction of multifunctional fusion proteins based on histone molecules to further improve the transfection efficiency. Remarkably, histone has been demonstrated to achieve gene transfection in a synergistic manner with cationic polymers, affording to a significant improvement of transfection efficiency. In the review, we highlighted the recent developments and future trends in gene delivery mediated by histones or histone-based fusion proteins/peptides. This review also discussed the mechanism of histone-mediated gene transfection and provided an outlook for future therapeutic opportunities in the viewpoint of transfection efficacy and biosafety.
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