期刊
JOURNAL FOR IMMUNOTHERAPY OF CANCER
卷 3, 期 -, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1186/s40425-015-0051-7
关键词
Ovarian cancer; ID8; Antibody; TAM; Immune checkpoint blockade; IDO; Cancer vaccine; ACT
资金
- OvaCure
- Anticancer Fund
Despite advances in combinatorial chemotherapy regimens and the advent of intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer patients are inadequate. Immunotherapy offers a novel and promising therapeutic strategy for treating ovarian tumors. Following the demonstration of the immunogenicity of ovarian tumors, multiple immunotherapeutic modalities have been developed. Antibody-based therapies, immune checkpoint blockade, cancer vaccines, and chimeric antigen receptor-modified T cells have demonstrated preclinical success and entered clinical testing. In this review, we discuss these promising immunotherapeutic approaches and emphasize the importance of combinatorial treatment strategies and biomarker discovery.
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