期刊
BIOSYSTEMS
卷 174, 期 -, 页码 37-48出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2018.10.008
关键词
Gene Regulatory Network Inference; Regression; Information theory; Bayesian networks; Boolean networks; Neural networks
资金
- European Union's Horizon 2020 research and innovation program [675585]
The study of biological systems at a system level has become a reality due to the increasing powerful computational approaches able to handle increasingly larger datasets. Uncovering the dynamic nature of gene regulatory networks in order to attain a system level understanding and improve the predictive power of biological models is an important research field in systems biology. The task itself presents several challenges, since the problem is of combinatorial nature and highly depends on several biological constraints and also the intended application. Given the intrinsic interdisciplinary nature of gene regulatory network inference, we present a review on the currently available approaches, their challenges and limitations. We propose guidelines to select the most appropriate method considering the underlying assumptions and fundamental biological and data constraints.
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