期刊
BIOSENSORS & BIOELECTRONICS
卷 124, 期 -, 页码 150-160出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.10.024
关键词
Portable imaging platform; Cell-based assays; Microfluidic device; Point-of-care diagnosis
类别
资金
- National Natural Science Foundation of China [31800713]
- Hefei Institute of Physical Science, China [YZJJ2018QN22]
- Key Research and Development Program of Anhui Province of China [1804a09020051]
- Science and Technology Major Program of Anhui Province of China [16030801123]
- National Science and Engineering Research Council of Canada
- Canadian Institutes of Health Research
Cell-based assays including both cell identification assays and cell functional assays are broadly used in life science research and for medical applications. Traditionally, cell-based assays are performed in professional laboratories. Although such an approach is reliable, it significantly limits the accessibility of cell-based assays by many researchers without specialized cell imaging facilities and does not permit on-site use at most clinics. Over recent years, growing efforts have been made to overcome this limitation by developing various portable cell imaging platforms. Herein, we provide a timely review on the recent development of portable imaging systems and their biomedical applications. We describe the respective applications of three main classes of portable imaging technologies including miniaturized microscope, lens-free imaging device and smartphone-based microscope for cell-based assays. We conclude by discussing our views on the opportunities, problems and future directions of this emerging field.
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