期刊
SCIENCE ADVANCES
卷 1, 期 11, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.1500737
关键词
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资金
- Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia
- Lady Tata Memorial Trust
- Spanish Ministerio de Educacion y Ciencia [SAF2013-48926-P]
- AGAUR (Agencia de Gestio d'Ajuts Universitaris i de Recerca)
- La Marato TV3
- Fundacion Vencer El Cancer (VEC)
- Spanish Ministry of Economy and Competitiveness
- European Commission [277899]
- Ia Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales
- Centro de Excelencia Severo Ochoa [SEV-2012-0208]
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic model for epigenetic maintenance of gene transcription programs. Despite intensive research efforts to unveil the molecular mechanisms of action of PcG proteins, several fundamental questions remain unresolved: How many different PcG complexes exist in mammalian cells? How are PcG complexes targeted to specific loci? How does PcG regulate transcription? In this review, we discuss the diversity of PcG complexes in mammalian cells, examine newly identified modes of recruitment to chromatin, and highlight the latest insights into the molecular mechanisms underlying the function of PcGs in transcription regulation and three-dimensional chromatin conformation.
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