期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 29, 期 1, 页码 66-72出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.11.005
关键词
Benzofuran-tetrazole derivatives; Molecular hybridization; Amyloid-beta aggregation; TcAChE-E2020 complex
资金
- UGC
- ICMR New Delhi, India
- CSIR
A series of novel Benzofuran-tetrazole derivatives were successfully synthesised by integrating multicomponent Ugi-azide reaction with the molecular hybridization approach. Interestingly, a number of synthesized derivatives (5c, 5d, 5i, 5l, 5q and 5s) exhibited significant reduction of aggregation of human amyloid beta peptide, expressing on transgenic Caenorhabditis elegans (C. elegans) strain CL4176. Further, in silico docking results have evidenced the exquisite interaction of active compounds with the help of TcAChE-E2020 complex. These findings underscore the potential of these hybrids as lead molecules against Alzheimers's disease.
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