期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 29, 期 5, 页码 724-728出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.01.008
关键词
HCV; Amidinourea; Polyamine; HCV translation; RNA IRES
资金
- Royal Society [RG160870]
- MRC [MC_ UU12014/2]
- MRC [MC_UU_12014/2] Funding Source: UKRI
Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.
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