期刊
BIOLOGICAL PSYCHIATRY
卷 85, 期 10, 页码 792-801出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2018.10.008
关键词
Anxiety; Bed nucleus of the stria terminalis; Intranasal oxytocin; Nucleus accumbens; Stress; Ventral tegmental area
资金
- National Institutes of Health (NIH) [R01 MH103322]
- NIH [T32-AA007456]
Oxytocin (OT) is widely known for promoting social interactions, but there is growing appreciation that it can sometimes induce avoidance of social contexts. The social salience hypothesis posed an innovative solution to these apparently opposing actions by proposing that OT enhances the salience of both positive and negative social interactions. The mesolimbic dopamine system was put forth as a likely system to evaluate social salience owing to its well-described role in motivation. Evidence from several sources supports the premise that OT acting within the nucleus accumbens and ventral tegmental area facilitates social reward and approach behavior. However, in aversive social contexts, additional pathways play critical roles in mediating the effects of OT. Recent data indicate that OT acts in the bed nucleus of the stria terminalis to induce avoidance of potentially dangerous social contexts. Here, we review evidence for neural circuits mediating the effects of OT in appetitive and aversive social contexts. Specifically, we propose that distinct but potentially overlapping circuits mediate OT-dependent social approach or social avoidance. We conclude that a broader and more inclusive consideration of neural circuits of social approach and avoidance is needed as the field continues to evaluate the potential of OT-based therapeutics.
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