期刊
BIOLOGICAL PSYCHIATRY
卷 84, 期 11, 页码 797-802出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2017.03.025
关键词
ATP; Bioenergetics; Imaging; Mania; Mitochondria; MRS
资金
- National Institute of Mental Health [K24MH104449]
- Program for Neuropsychiatric Research at McLean Hospital
BACKGROUND: Brain energy metabolism is critical for supporting synaptic function and information processing. A growing body of evidence suggests abnormalities in brain bioenergetics in psychiatric disorders, including both bipolar disorder (BD) and schizophrenia. P-31 magnetic resonance spectroscopy provides a noninvasive window into these processes in vivo. Using this approach, we previously showed that patients with BD show normal adenosine triphosphate (ATP) and phosphocreatine levels at rest but cannot maintain normal ATP levels in the visual cortex during times of high energy demand (photic stimulation). Because ATP is replenished from phosphocreatine via the creatine kinase reaction, we have now measured the creatine kinase forward reaction rate constant in BD. METHODS: We studied 20 patients experiencing a first episode of BD and 28 healthy control participants at 4T and quantified creatine kinase forward reaction rate constant using P-31 magnetization transfer magnetic resonance spectroscopy as described previously. RESULTS: We found a significant reduction in creatine kinase forward reaction rate constant in the BD group (F = 4.692, p =.036), whereas brain ATP and phosphocreatine concentrations, as well as brain parenchymal pH, were normal. CONCLUSIONS: These results pinpoint a specific molecular mechanism underlying our previous observation of an inability to replenish brain ATP during times of high energy demand in BD.
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