期刊
BIOLOGICAL CHEMISTRY
卷 400, 期 6, 页码 687-698出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2018-0328
关键词
biophysics; cell biology; mechanical memory; mechanotransduction
资金
- German Research Council through the DFG-ANR program [GR 3399/6-1]
- Collaborative Research Centre [SFB863]
- Human Frontier Science Program [RGP0024]
The ability of cells to sense and respond to mechanical stimuli is crucial for many developmental and homeostatic processes, while mechanical dysfunction of cells has been associated with numerous pathologies including muscular dystrophies, cardiovascular defects and epithelial disorders. Yet, how cells detect and process mechanical information is still largely unclear. In this review, we outline major mechanisms underlying cellular mechanotransduction and we summarize the current understanding of how cells integrate information from distinct mechanosensitive structures to mediate complex mechanoresponses. We also discuss the concept of mechanical memory and describe how cells store information on previous mechanical events for different periods of time.
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